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KMID : 1134820080370010020
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 1 p.20 ~ p.26
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Antioxidative Effects of Skinned Mugwort (Artemisia vulgaris L.) Extracts on UV-Irradiated Hairless Mouse Skin
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Park Si-Hyang
Cho Duck-Moon
Choi Byeong-Dae
Choi Yeung-Joon
Choi Jin-Ho
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Abstract
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This study investigated the antioxidative effect of mugwort (Artemisia vulgaris L.) extracts in hairless mouse skin from oxidative stress induced by UV-irradiation. After topical application on hairless mouse back with basic skin lotion group (control), ascorbic acid group (AA-0.5%, AA-1.0%, AA-2.0%, and AA-5.0%), and mugwort extract group (ME-0.5%, ME-1.0%, ME-2.0%, and ME-5.0%), the animals were irradiated to increasing doses of UVB (60 mJ～100 mJ) for 4 weeks. Hydrogen peroxide of hairless mouse skin homogenate significantly decreased in 2% (p<0.05) and 5% (p<0.05) of ME and AA groups. Hydroxyl radicals were decreased significantly in both of 2% and 5% ME groups as compared to AA groups (p<0.05). Oxidative stress levels deduced by oxidized protein contents were greatly decreased (14.6～18.5%) in all ME treatment groups, while only at 2% of AA treatment group. Lipid peroxide contents were greatly inhibited in all ME and AA
treatment groups (p<0.01). Application of ME significantly increased catalase activity, over 25% in all mugwort and AA groups. Glutathione peroxidase activities were increased up to 20.5%～32.8% in 2.0% and 5% ME groups, whereas it increased in all AA groups. These results suggested that mugwort extract was more effective than that of ascorbic acid in protecting hairless mouse skin from photo-irradiation, and can be used as an potential anti-aging cosmetic ingredients.
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KEYWORD
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mugwort (Artemisia vulgaris L.) extract, ascorbic acid, UVB, antioxidative effect, skin
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